HPV: Teenage vaccine is causing death and injury

 

The vaccine has been given routinely to adolescent girls when they are 12 and 13 for several years now in America, and the pattern of deaths and side effects is now starting to be repeated in other countries, such as the UK, which have only recently introduced the vaccine.

Judicial Watch, an American public watchdog group, has recently issued the latest figures on the vaccine’s safety. Of the 140 adverse events this year, several have included miscarriage and onset of Guillain-Barre syndrome, a nervous system disease that causes weakness and tingling in the arms and legs.

The vaccine has also loomed large in the public’s consciousness with the story of 13-year-old Jenny Tetlock who is now almost completely paralyzed after being given the vaccine.

Meanwhile, undeterred by these worrying stories, the UK government is widening the availability of its own HPV vaccine to include teenage girls aged between 17 and 18.

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Vacina contra câncer do intestino se mostra promissora

NEW YORK – Uma vacina experimental contra o câncer de cólon pode ajudar a tratar muitos pacientes que já desenvolveram a doença, segundo um novo estudo.Em um estudo anterior, esta vacina não pareceu melhorar as chances de cura dos pacientes. Mas a vacina oferece vantagens para algumas pessoas, segundo o Dr. Jules Harris, de Chicago.No subgrupo de pacientes que apresentou a maior resposta imune à vacina, 85% deles sobreviveu por mais de 5 anos, contra 45% dos que apresentaram resposta moderada à vacina. “Nós achamos que vacinações repetidas podem ser mais eficientes,” ele diz.O Dr. Harris e seus colaboradores escolheram 412 pacientes americanos entre 1986 e 1993 que tinham câncer de cólon que havia se espalhado para os linfonodos e tecidos adjacentes mas não para outros órgãos do corpo.

Os médicos operaram todos os pacientes, retirando os tumores. Em aproximadamente metade destes pacientes, os médicos retiraram uma porção do tumor do paciente, trataram estas células com irradiação, e fizeram uma vacina contra o tumor do próprio paciente.

Estes pacientes receberam três doses desta vacina em intervalos, começando 3 a 4 semanas após a cirurgia. Os pesquisadores monitoraram estes pacientes por 8 anos.

Entre os pacientes que reagiram à vacina, apresentando reação no local da injeção, as taxas de sobrevida variaram de acordo com o tamanho da reação. Entre aqueles com reação menor que o diâmetro de um lápis, 45% sobreviveu por menos de 5 anos, enquanto 85% daqueles que mostraram uma cicatriz do tamanho de uma moeda sobreviveram este tempo ou mais.

O Dr. Harris disse à Reuters Health que a cicatriz se tornou uma forma de avaliar o prognóstico do paciente, sendo que os que tiverem maior cicatriz terão chance de evoluir melhor.

Tentativas de melhorar a qualidade das vacinas também podem melhorar a reação à esta, de acordo com os pesquisadores.

FONTE: Journal of Clinical Oncology 2000;18:148-157.
Publicado em Bibliomed Saúde

Copyright © 2002 Bibliomed, Inc.

 

 

 

 

 

 

 

 

G E N O A 

Por favor, divulguem esta maravilha brasileira!

 

Já existe vacina contra alguns tipos de câncer.

Foi desenvolvida por cientistas brasileiros, mostrando-se eficaz em 80% dos casos, tanto no estágio inicial como em fase mais avançada da doença.

A vacina é fabricada utilizando-se um pequeno pedaço do tumor do próprio paciente.

Em 30 dias está pronta e é remetida para o médico oncologista do paciente.

Os cientistas desenvolveram a vacina no Hospital Sirio Libanês – Grupo Genoa (telefone 0800-7737327).

 

Se preferirem, entrem no site

www.vacinacontraocancer.com.br

e obtenham maiores informações a respeito.

 

Essa, sim, é o tipo de mensagem que merece ser repassada.

 

 

 

 

Live Earth India

Live Earth India Press ConferenceLive Earth is doing it again! On December 7, 2008, there will be a concert for a climate in crisis in Mumbai featuring world-renowned musicians and performers, environmental advocates and celebrities from India, the U.S. and beyond. Live Earth India will feature personal and policy solutions to the climate crisis, offer support for India’s most important environmental issues and causes, and provide a platform so India can continue its global climate leadership.

India didn’t cause the climate crisis, but it will suffer some of the most serious consequences of global warming (drought and flooding could produce hundreds of millions of climate refugees) if we don’t act now. We are honored to bring Live Earth to India and with participants like Mr. Gore, Indian environmental leader Dr. R. K. Pachauri, actor and Live Earth India spokesperson Amitabh Bachchan, and Jon Bon Jovi. Along with amazing entertainers we will benefit TERI’s Light A Billion Lives campaign and The Climate Project India, which are dedicated to promoting awareness and finding solutions to current climate situations while alleviating poverty. Please check out daily updated information on our new website at http://liveearth.org/category/india or check out video from our Mumbai press conference at http://liveearth.org/category/press/ Live Earth India will be broadcast in India on STAR Plus and worldwide online at MSN: more updates soon on “Friends of Live Earth India” and how you can watch it at home!

Live Earth Votes!

Rock the VoteIf you visit http://www.liveearth.org you’ll notice some changes – one of the most important components of our new website is Live Earth Vote. When enough of us do and say the same thing, no politician can afford to ignore us. Register to vote today and cast your vote for the climate on November 4, 2008. At Live Earth Vote (http://liveearth.org/vote) you can register to vote (hurry – many states close voter registration on October 6th!) and find out more about how the candidates stack up on environmental issues. You can also register by using this link – don’t wait!!
http://www.rockthevote.com/rtv_register.html?api_key=0LhlC2vLcOFWDLaULQNRcvD0WEQ&ms=siu

Live Earth and Pepsi Recycling

Pepsi Recycling and Live EarthLive Earth and Pepsi have been partners since our Giants Stadium show last year (maybe you were there and saw the dinosaur sculptures made out of Pepsi cans?). This year in North America you might see one of 500 million Pepsi cans that have been produced in partnership with Live Earth. We’ve created a fun website to support the campaign – http://www.liveearth.org/pepsi – since the cans are reaching the market now we included ways to register to vote, information on candidates, and some fun ideas about what you can do with a pepsi can (check out the Pepsi can yeti!) – upload your own photos of pepsi can sculpture or other creative ways to reuse and recycle!

Novos tratamentos são alternativas à

lipoaspiração

Resultados são menos visíveis, mas efeitos colaterais são reduzidos

 

Quem não quer se arriscar fazendo uma lipoaspiração pode experimentar um dos vários tratamentos estéticos que usam tecnologias como o laser, o ultra-som e a radiofreqüência para enxugar medidas. Como é de se esperar, os resultados são menos visíveis do que uma intervenção cirúrgica, mas também quase não têm efeitos colaterais e não interferem na rotina. 

– Recomendo este tipo de tratamento para as pessoas que já estão no peso do ideal, têm uma dieta equilibrada, fazem exercícios com regularidade e mesmo assim continuam com gorduras localizadas em áreas como culote, abaixo do umbigo, cintura ou região dos joelhos. Nestes casos, os aparelhos costumam ser bastante eficazes e o paciente pode perder até três centímetros do local por sessão – explica a dermatologista Daniela Nunes, da Sociedade Brasileira de Dermatologia (SBD).

O dermatologista Jardis Volpe, também da SBD, acredita que o aparelho tem uma qualidade adicional: ajuda a estimular o sistema linfático, responsável pelo o acúmulo de toxinas, e por isso melhora quadros de retenção de líquidos e má circulação.

– Os aparelhos também atuam em todos os tipos de celulite, já que reduz os edemas e as fibroses que acentuam o aspecto “casca de laranja” – completa.

Durante o tratamento, os médicos sugerem que o paciente também faça dieta e exercícios para acelerar e manter os resultados. Em geral, o procedimento é feito em séries de cinco a dez sessões, com intervalos de duas semanas entre cada aplicação. Quem optar por uma intervenção deste tipo também deve lembrar que o preço total pode acabar tão caro quanto uma cirurgia estética. Um pacote com cinco sessões custa, em média, de um a dois mil reais.

Confira os tratamentos considerados os mais eficazes pelos médicos atualmente:

 

AGÊNCIA O GLOBO

Accent
Indicado para flacidez e quadros avançados de celulite, é moda entre as celebridades que querem enrijecer a barriga no pós-parto. O aparelho emite radiofreqüência para estimular as células a produzirem mais colágeno, substância que dá sustentação à pele. É contra-indicado para mulheres com dispositivo intra-uterino (DIU). São necessárias no mínimo seis sessões para se ter um bom resultado.
Carboxiterapia
Consiste na injeção de gás carbônico nas camadas superficiais da pele. O gás ajuda a estimular a produção de colágeno nas células e acelera a quebra das células de gordura. Os melhores resultados são na região das coxas e do bumbum, e é bastante eficaz para quem tem uma celulite resistente. É contra-indicado para diabéticos.
Ultracontour e Ultrashape
Ambos emitem ondas de ultra-som de alta intensidade que promovem a quebra das células de gordura. É indicado para quem já atingiu o peso ideal e não consegue se livrar de gorduras localizadas. Em apenas uma sessão, é possível perder até três centímetros nas medidas.
Ulift
Tem a mesma tecnologia que o Ultracontour e o Ultrashape, mas é programado para tratar as regiões com muita celulite. Não é indicado para a perda de medidas, mas é considerado pelos dermatologistas a melhor opção para as mulheres que querem reduzir o aspecto dos furinhos.

 

A lipoaspiração inteligente


Lipoaspiração é a cirurgia plástica mais realizada no mundo (ganha até dos famosos implantes de silicone). O motivo é simples: levanta a mão quem tem alguma gordurinha sobrando em alguma parte do corpo? Mesmo as mulheres mais magras acabam tendo um pouco de gordura em algum lugar incômodo.

Mesmo as magrinhas costumam ter gordurinhas em lugares indesejados.

Mesmo as magrinhas costumam ter gordurinhas em lugares indesejados.

Não estou falando de obesidade ou de sobrepeso (para isso não adianta fazer nenhum tipo de lipo), mas daquela área de gordura que fica sobrando mesmo depois de dieta e ginástica, aquela que dá vontade de passar a faca, sabe? Pode ser um culote maior, um joelho mais gordo (meu caso), uma barriguinga que sobrou da gravidez e que não sai nem com milhares de abdominais. Enfim, todo mundo entendeu do que eu estou falando né?
A técnica mais moderna para resolver esse problema que incomoda praticamente 100% das mulheres é a laserlipólise, também conhecida como Smartlipo, ou, exageradamente como lipo da hora do almoço. A laserlipólise incorpora uma tecnologia européia, a mais moderna no tratamento da gordura localizada, utilizada com sucesso desde 1997 na Itália, Alemanha e Argentina e Estados Unidos. No Brasil, as primeiras cirurgias do tipo foram realizadas em 2000 , no Rio Grande Sul, pelo cirurgião plástico Alberto Goldman. As indicações são abdome, cintura, coxas, costas, joelhos, culotes, papada e rosto.
Como é realizada?

A luz do laser marca de depois queima as células de gordura

A luz do laser marca de depois queima as células de gordura

Primeiro o paciente recebe a anestesia (que pode ser local ou peridural), e pode combinar com o médico se prefere usar sedativos ou não. Após a anestesia, a equipe médica e o paciente colocam óculos de proteção e é colocada uma cânula de laser bem fina. O objetivo do laser é romper as células de gordura liberar o seu conteúdo oleoso. Essa gordura liberada então é aspirada por uma cânula bem mais fina do que a utilizada na lipoaspiração tradicional.
Quais as vantagens do método?
Além de liberar a gordura o laser coagula os pequenos vasos sanguíneos fazendo com que o paciente sangue menos e que menos manchas roxas sejam formadas após a cirurgia. Uma parte da gordura queimada pelo laser e que não foi aspirada é absorvida pelo próprio organismo e depois eliminada pelos rins.
O procedimento pode ser realizado em hospitais ou em clínicas especializadas. Em geral não é necessário internação e o paciente recebe alta no mesmo dia. Mas ao contrário do que sugere o nome, não dá para fazer a lipo na hora do almoço e depois voltar ao trabalho. A laserlipólise também promete melhorar a flacidez da pele – o laser estimularia a produção de colágeno do local tratado. A cirurgia também atenua as ondulações da pele no caso da celulite, mas não as elimina por completo (é mais uma arma no combate a esse eterno problema femino).

Como é a recuperação?
Como os danos são menores, a recuperação costuma ser bem melhor do que na lipoaspiração tradicional, como menos manchas roxas, menos inchaço. As cicatrizes são bem pequenas, com cerca de 2 milímetros. O retorno às atividades normais costuma se dar em poucos dias, de uma maneira progressiva.

Quais os riscos?
Apesar da evolução das técnicas, não existe cirurgia sem riscos. A laserlipólise é uma cirurgia como outra qualquer, com perigos nada desprezíveis: choque anafilático, infecções, necrose da pele, embolia pulmonar, que pode ser fatal. No caso específico da lipo a laser, podem ocorrer mais alguns problemas. Um deles é o risco de queimadura da pele pelo laser, que deve ser manipulado com muito cuidado. Outro problema é a promessa de redução da flacidez, já que estimular o colágeno pode retrair os tecidos e deixar a cicatriz irregular. O sangramento reduzido por causa do laser é outro ponto questionado já que cauterizar os vasos sanguíneos poderia causar falta de oxigênio e necrosar a pele.
Entre os médicos a técnica é polêmica, enquanto alguns defendem outros continuam acreditando que não há nada melhor do que a lipoaspiração tradicional para gordura localizada. Na verdade, como qualquer cirurgia, a experiência do cirurgião com a técnica conta muita, então quando um procedimento novo é lançado leva algum tempo até que as pessoas que executam atinjam a mesma destreza e os mesmos resultados que atingiam com um método antigo.
 
Para quem é indicada a cirurgia?
A cirurgia é indicada para pessoas saudáveis (ela é contra-indicada para fumantes – para quem sempre se contra-indica procedimentos estéticos eletivos, dados os riscos cirúrgicos aumentados para esses pacientes, pessoas com problemas cardíacos, no fígado ou nos rins) com gordura localizada que cause uma desarmonia no corpo. Não é indicada como método de emagrecimento e funciona melhor com pessoas acostumadas com atividade física (que possuem melhor tonicidade dos músculos) e que estejam no máximo 12 quilo acima do seu peso ideal. Boa elasticidade da pele também traz resultados melhores.
A técnica é aprovada pelo FDA americano e tem respaldo em estudos científicos como os listados abaixo, mas normalmente para se comparar um método cirúrgico a outro (no caso a laserlipólise com a lipoaspiração tradicional, são necessários pelo menos 20 anos de estudos, então ainda não temos todas as repostas sobre vantagens e desvantagens do método).
Ah sim: Uma lipo a laser custa entre 3.000 e 10 000 reais, dependendo da extensão da operação, valor semelhante ao cobrado por uma lipoaspiração tradicional.


Resumos de artigos científicos que avaliaram a técnica de laserlipólise aqui, aqui e aqui
Matéria na Revista Época (bem completa sobre o assunto)
Matéria na revista Boa Forma
Vídeo demonstrando a técnica (não indicado para as pessoas mais sensíveis)
 

ACUPUNCTURE FOR CANCER

Cancer

The thought of having cancer can be scary. But what exactly is cancer? And what does it do?

Cancer refers to any one of a large number of diseases characterized by the development of abnormal cells that divide uncontrollably and have the ability to infiltrate and destroy normal body tissue. Cancer can spread its abnormal cells throughout your body.

Being diagnosed with cancer can be frightening. But understanding what’s going on inside your body can help you be aware of what’s causing your feelings of anxiety. Knowing more about cancer may also help you feel more in control of your disease.

What causes cancer?

Cancer is caused by damage (mutations) in your DNA. Your DNA is like a set of instructions for your cells, telling them how to grow and divide. When a mutation occurs in your DNA, normal cells will repair the mutation or simply die. In cancer, your cells continue living with this mutation. As a result, they grow and divide in chaotic fashion.

Mutations in your DNA can be caused by:

Your own habits.
Certain lifestyle choices are known to cause cancer. Smoking, drinking more than one drink a day (for women) or two drinks a day (for men), being overweight, damage to skin unprotected by sunscreen, and unsafe sexual behaviors can lead to the mutations that cause cancer. You can break these habits to lower your risk of cancer — though some habits are easier to break than others.

Your environment.
The environment around you may contain harmful chemicals that can cause mutations in your genes. Even if you don’t smoke, you might breathe secondhand smoke if you go places where people are smoking or you live with someone who smokes. Chemicals in your home or work environment, such as asbestos and benzene, can also cause cancer.

Your family history.
Some mutations in your DNA can be traced back to your parents. If cancer is common in your family, it’s possible that mutations are being passed from one generation to the next. You might be a candidate for genetic screening to see whether you have mutations that might increase your risk of cancer. Keep in mind that having an inherited genetic mutation doesn’t necessarily mean you’ll get cancer.

Chronic conditions.
Some chronic health conditions, such as ulcerative colitis, can develop into cancer. Talk to your doctor about your risk.

Much is still unknown about cancer. Some people with many risk factors don’t develop cancer, and some people with no apparent risk factors develop cancer nonetheless.

How does cancer grow?

Cancer cells grow in an uncontrolled manner. One malignant cell becomes two, two become four, four become eight, and so on, until a mass of cells (a tumor) is created. The tumor interferes with the normal functioning of healthy tissue and can spread to other parts of your body.

Not all tumors are cancerous, and not all cancers form tumors. For example, leukemia is a cancer that involves blood, bone marrow, the lymphatic system and the spleen but doesn’t form a single mass or tumor.

Cancer invades and destroys normal tissue. It can also produce chemicals that interfere with body functions. For instance, some lung cancers secrete chemicals that alter the levels of calcium in your blood, affecting nerves and muscles and causing weakness and dizziness.

Cancer can also spread (metastasize) and invade healthy tissue in other areas of your body. Cancer can take years to develop. By the time a cancerous mass is detected, it’s likely that 100 million to 1 billion cancer cells are present, and the original cancer cell may have been dividing for five years or more.

Traditional Chinese Medicine has a different approach to treating cancer patients compared to modern medicine. Traditional Chinese Medicine is to strengthen and build a patient’s Qi (energy) to fight the cancer.
Acupuncture has also proved to be effective in treating cancer patients side effect symptoms from radiation therapy and chemotherapy.

Stress

What is the stress response?

Often referred to as the “fight-or-flight” reaction, the stress response occurs automatically when you feel threatened. Your pituitary gland, located at the base of your brain, responds to a perceived threat by stepping up its release of adrenocorticotropic hormone (ACTH), which signals other glands to produce additional hormones. When the pituitary sends out a burst of ACTH, it’s like an alarm system going off deep in your brain. This alarm tells your adrenal glands, situated atop your kidneys, to release a flood of stress hormones into your bloodstream. These hormones — including cortisol and adrenaline — focus your concentration, speed your reaction time, and increase your strength and agility.

 
How stress affects your body

After you’ve fought, fled or otherwise escaped your stressful situation, the levels of cortisol and adrenaline in your bloodstream decline. As a result, your heart rate and blood pressure return to normal and your digestion and metabolism resume a regular pace. But if stressful situations pile up one after another, your body has no chance to recover. This long-term activation of the stress-response system can disrupt almost all your body’s processes, increasing your risk of obesity, insomnia, digestive complaints, heart disease and depression.

                          Digestive system. It’s common to have a stomachache or diarrhea when you’re stressed. This happens because stress hormones slow the release of stomach acid and the emptying of the stomach. The same hormones also stimulate the colon, which speeds the passage of its contents. Chronic stress can also lead to continuously high levels of cortisol. This hormone can increase appetite and cause weight gain.

                          Immune system. Chronic stress tends to dampen your immune system, making you more susceptible to colds and other infections. Typically, your immune system responds to infection by releasing several substances that cause inflammation. In response, the adrenal glands produce cortisol, which switches off the immune and inflammatory responses once the infection is cleared. However, prolonged stress keeps your cortisol levels continuously elevated, so your immune system remains suppressed.

In some cases, stress can have the opposite effect, making your immune system overactive. The result is an increased risk of autoimmune diseases, in which your immune system attacks your body’s own cells. Stress can also worsen the symptoms of autoimmune diseases. For example, stress is one of the triggers for the sporadic flare-ups of symptoms in lupus.

                          Nervous system. If your fight-or-flight response never shuts off, stress hormones produce persistent feelings of anxiety, helplessness and impending doom. Oversensitivity to stress has been linked with severe depression, possibly because depressed people have a harder time adapting to the negative effects of cortisol. The byproducts of cortisol act as sedatives, which contribute to the overall feeling of depression. Excessive amounts of cortisol can cause sleep disturbances, loss of sex drive and loss of appetite.

                          Cardiovascular system. High levels of cortisol can also raise your heart rate and increase your blood pressure and blood lipid (cholesterol and triglyceride) levels. These are risk factors for both heart attacks and strokes. Cortisol levels also appear to play a role in the accumulation of abdominal fat, which gives some people an “apple” shape. People with apple body shapes have a higher risk of heart disease and diabetes than do people with “pear” body shapes, where weight is more concentrated in the hips.

                          Other systems. Stress worsens many skin conditions — such as psoriasis, eczema, hives and acne — and can be a trigger for asthma attacks.

 
Individual reactions to stress

Your reaction to a specific stressor is different from anyone else’s. Some people are naturally laid-back about almost everything, while others react strongly at the slightest hint of stress — and most fall somewhere between those extremes. Genetic variations may partly explain the differences. The genes that control the stress response keep most people on a fairly even keel, only occasionally priming the body for fight or flight. Overactive or underactive stress responses may stem from slight differences in these genes.

Life experiences may increase your sensitivity to stress as well. Strong stress reactions sometimes can be traced to early environmental factors. People who were exposed to extreme stress as children tend to be particularly vulnerable to stress as adults.

 
Reducing the effects of stress

Stress develops when the demands in your life exceed your ability to cope with them. It follows, then, that you can manage stress by:

                          Changing your environment so that the demands aren’t so high

                          Learning how to better cope with the demands in your environment

                          Doing both

Here are some helpful techniques:

                          Look after your body. To handle stress, your body requires a healthy diet and adequate rest. Exercise also helps, by distracting you from stressful events and releasing your nervous energy.

                          Learn to relax. It’s the polar opposite of the stress response. Deep-breathing exercises may put you in a relaxed state. Follow these steps:

  1. Inhale through your nose to a count of 10. As you inhale, your upper abdomen should rise — not your chest.
  2. Exhale slowly and completely, to a count of 10.
  3. Repeat five to 10 times. Try to do this several times every day, even when you’re not feeling stressed.

If you have persistent trouble relaxing, consider taking up meditation or studying yoga or tai chi, Eastern disciplines said to focus your mind, calm your anxieties and release your physical tension. Therapeutic massage may also loosen taut muscles and calm frazzled nerves. Acupuncture can unblock the energy channel of the body and help the body to relax

 Depression

Depression is a disorder that affects your thoughts, moods, feelings, behavior and physical health. People used to think it was “all in your head” and that if you really tried, you could “pull yourself out of it.” Doctors now know that depression is not a weakness, and you can’t treat it on your own. It’s a medical disorder with a biological or chemical basis.

Sometimes, a stressful life event triggers depression. Other times depression seems to occur spontaneously with no identifiable specific cause. Whatever the cause, depression is much more than grieving or a bout of the blues.

Depression may occur only once in a person’s life. Often, however, it occurs as repeated episodes over a lifetime, with periods free of depression in between. Or it may be a chronic condition, requiring ongoing treatment over a lifetime. The disorder affects more than 18 million Americans of all ages and races.

Until now, modern medicine could offer people with depression only a pill or the prospect of talking it out, sometimes for years. Soon, though, doctors may offer an alternative – the 5,000 year-old Chinese art of Acupuncture.
In a recent University of Arizona study, clinically depressed women received eight weeks of acupuncture, in which practitioners gently pressed needles into specific body points to correct imbalances believed to trigger illness. The results: After getting treatments aimed at relieving depression, about two-thirds were cured of the condition, a rate similar to that achieved with antidepressants and psychotherapy.
(Researchers ruled out the placebo effect by giving one group acupuncture at points believed to be unrelated to depression.)
Although the study, which was funded by the National Institutes of Health’s Office of Alternative Medicine, is preliminary, author John Allen, Ph.D., believes acupuncture eventually may benefit people for whom other treatments fail. Unlike antidepressant drugs, for instance, acupuncture has no side effects. And Allen predicts that it may offer the best way yet to forestall future episodes of depression. That’s a significant worry, since people who’ve suffered one bout of depression have a 50 percent chance of enduring another.

The TCM (traditional Chinese medicine) model of the body is a culturally based philosophy of how the human body works.

The elements of the TCM model of the body are the Fundamental Substances; Qi, Blood, Jing (Essence), Shen (Mind) that nourish and protect the Zang-Fu organs; and the meridians (jing-luo) which connect and unify the body. Every diagnosis is a “Pattern of disharmony” that affects one or more organs (such as “Spleen Qi Deficiency” or “Liver Fire Blazing” or “Invasion of the Stomach by Cold”), and every treatment is centered on correcting the disharmony.

Unlike the Western anatomical model which divides the physical body into parts, the Chinese model is more concerned with function. Thus, the TCM Spleen is not a specific piece of flesh, but an aspect of function related to transformation and transportation within the body, and of the mental functions of thinking and studying. Indeed, the San Jiao or Triple Burner has no anatomical correspondent at all, and is completely a functional entity.

Chinese medicine is a coherent and independent system of thought, it has been developed over two millennia. Based on ancient texts, it is the results of a continuous process of critical thinking, as well as extensive clinical observation and testing. It represents a thorough formulation and reformulation of material by respected clinicians and theoreticians. It is rooted in the philosophy, disease is caused by an unhealthy relationship with nature and that treatment lies in establishing balance with nature, Yin/Yang and five elements.

Traditional Chinese medicine is holistic, based on the idea that no single part of the body can be understood except in its relation to the whole. A symptom, therefore, is not traced back to a cause, but is looked at as a part of a totality. If a person has a symptom, Chinese medicine wants to know how the symptom fits into the patient’s entire bodily pattern. A person who is well, or “in harmony”, has no distressing symptoms and expresses mental, physical, and spiritual balance. When that person is ill, the symptom is only one part of a complete bodily imbalance that can be seen in other aspects of his or her life and behavior. Understanding that overall pattern with the symptom as part of it, is the challenge of Chinese medicine.

People all over the world are using TCM including acupuncture and Chinese herbal medicine.

 

Maitake D-fraction: Healing and Preventive Potential for Cancer

Hiroaki Nanba, Ph.D.

Abstract

I have been studying medicinal mushrooms for the last 15 years and have reported that of all mushrooms studied, Maitake Mushroom (Grifola frondosa) has the strongest activity in tumor growth inhibition both in administered orally and intraperi-toneally.1,2,3 In this report, Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibition of formation of the secondary focus due to metastasis of tumor cells in lymph and/or blood. In the tests of cancer inhibition rates on mice bearing MM46 (breast cancer), they were bred for one month with foods containing 20% edible mushroom powder. The result was that Maitake outperformed all other mushrooms. Through the 31 day oral administration, total remission of the tumor was visibly confirmed on four out of ten Maitake fed mice. The remaining six rodents also indicated almost 90% suppression rate compared to untreated (control) mice. Most other mushroom extracts are reported ineffective when given orally.4,5 The results of human studies on Maitake D-fraction is reported which indicated strong potential of Maitake D-fraction for cancer treatment.

 

Introduction

Maitake (Pron. “my-tah-key”) is indigenous to northern part of Japan. The basket-ball sized mushroom, weighing sometimes over 50 pounds, grows on the foot of old Japanese oak trees. For hundreds of years, this rare and tasty mushroom has been prized in traditional Japanese herbology. Maitake literally means “Dancing Mushroom”. People who found the mushroom in deep mountain valleys started dancing with joy since they knew its delicious taste and the health benefits. Also, in the feudal era, it could be exchanged with the same weight of silver. Maitake was, and still is, one of the most valuable and expensive mushrooms.
This legendary giant mushroom has been available by cultivation since the mid 1980s which gave opportunities for mycologists and pharmacologists to study the various medicinal properties on the mushroom as claimed in anecdotes and folklore. In addition to its antitumor effect, anti-hypertension, anti-diabetes, anti-obesity and anti-hepatitis activities have been found in Maitake. Its anti-HIV activity was also confirmed by both Japan National Institute of Health and U.S. National Cancer Institute in early 1992. 

 

 

Maitake D-fraction
Among the various fractions in the process of standardization of the mushroom extraction, it is known that Maitake D-fraction is most potent in enhancing the immune system, demonstrating highest cancer inhibition in oral administration.3,6 The protein-bound Maitake D-fraction is the acid-insoluble, alkali-soluble and hot water extractable fraction (1,6 beta-glucans carrying 1,3 branched chains) with molecular weight of about one million. Maitake D-fraction has strong ability to potentiate and activate the cellular immune system. We investigated how much each immune-competent cell is activated by the administration of Maitake D-fraction. Mice in experiment groups were administered either 0.5 mg/Kg of D-fraction by I.P. injection for 10 days or 1.0 mg/Kg of D-fraction by oral administration for 10 days. The activity of Natural Killer cells, cytotoxic T-cells and delayed-hypersensitive T-cells were all increased by 1.5-2.2 times by Maitake D-fraction. Also, it was observed that production of interleukin-1 (which activates T cells), and super-oxide anion ( which damages tumor cells) were enhanced. The production of interleukin-2 was also observed to increase by 1.7 fold (Table 1). From these results it may be concluded that the cellular immune-competent cells ability to inhibit tumor growth may be potentiated by Maitake D-fraction.
The purified D-fraction extract and Maitake crude tablets were tested using mice to investigate acute and chronic toxicity. Based on a previous animal test which indicates the optimal dose of 1mg/kg of D-fraction for anti-tumor activity, ten times more dosage was employed intraperit-oneally for 30 days. On the 31st day, no abnormal symptoms were observed, when mice were sacrificed and their organs and blood were checked. Furthermore, 5 mg/kg of D-fraction was injected for 120 days and the toxicity was investigated in the same manner. Since no abnormality was found in this test, we came to the conclusion that there is no toxicity in the D-fraction. At present, it is not permitted to inject D-fraction into the human body, therefore, in our study the D-fraction was used via oral administration. Maitake tablets were also investigated for possible toxicity. Maitake has been appreciated by the Japanese people as the premier culinary mushroom for hundreds of years, and it is therefore unlikely to exhibit any toxicity. However, we did the same test as was done with the D-fraction, by feeding it to mice by mixing it in their diet at a 1:4 ratio for a period of 13 months. After completion of these tests, we concluded that both Maitake D-fraction and the tablets made of Maitake crude powder were safe with no toxicity.

 

Clinical Results
A number of animal tests have confirmed Maitake’s strong ability in cancer inhibition.7-10 but human trials have not been conducted until recently. A non-randomized clinical study using D-fraction was conducted to see if it is effective against advanced cancer patients as it is against animals. A total of 165 cancer patients in stage III-IV, from 25-65 years old, participated in the study and the data was collected under the cooperation of their medical doctors with major university hospitals and cancer treatment clinics in the western part of Japan. Patients were either taking Maitake D-fraction with crude powder tablets only, or Maitake D-fraction, crude tablets in addition to chemotherapy. Tumor regression or significant symptom improvements was observed in 11 out of 15 breast cancer patients, 12 out of 18 lung cancer patients and 7 out of 15 liver cancer patients. If Maitake was taken in addition to chemotherapy together, these response rates improved by 12-28 percent.

Clinical Results
A number of animal tests have confirmed Maitake’s strong ability in cancer inhibition.7-10 but human trials have not been conducted until recently. A non-randomized clinical study using D-fraction was conducted to see if it is effective against advanced cancer patients as it is against animals. A total of 165 cancer patients in stage III-IV, from 25-65 years old, participated in the study and the data was collected under the cooperation of their medical doctors with major university hospitals and cancer treatment clinics in the western part of Japan. Patients were either taking Maitake D-fraction with crude powder tablets only, or Maitake D-fraction, crude tablets in addition to chemotherapy. Tumor regression or significant symptom improvements was observed in 11 out of 15 breast cancer patients, 12 out of 18 lung cancer patients and 7 out of 15 liver cancer patients. If Maitake was taken in addition to chemotherapy together, these response rates improved by 12-28 percent.

The criteria to judge the effectiveness are established as follows. A positive response is defined as one of the following:
1) if the size of tumor in CT or MRI screen reduced or stayed unchanged.
2) if the value of tumor mark decreased.
3) if T, N or M factors reduced or remained unchanged.
4) if the remaining life expectancy indicated by the doctor was prolonged by more than 4 times.
As can be seen, these results suggest that breast, lung and liver cancers were improved by Maitake, but it was less effective against bone and stomach cancers or leukemia. The following are some of the typical cases which demonstrated improvements by taking Maitake D-fraction and tablets.

51 years old, male, Liver cancer (hepatocellular carcinoma)
He had received Adriamycin (ADM) since 1993, but refused it because of little effectiveness and severe side effects of chemotherapy. He took 35 mg of D-fraction and 4 g of Maitake caplet per day. After 8 months, the level of bilirubin and albumin are improved as well as T and N factors. The value of bilirubin reduced to 1.8 mg/dL from 4.7 mg/dL. Also, albumin improved from 2.1 g/dL to 3.7 g/dL and the prothrombin activation was increased to 92% from 36%. Meanwhile, T-factor improved from 3-4 to 1-2 and N-factor changed from 0-1 to 0. T-factor 3 means that tumor diameter is more than 2 cm and some tumors remove into blood vessels. N-factor 1 means that the tumors metastasized to lymph nodes.

56 years old, female, Liver cancer (hepatocellular carcinoma)

She was diagnosed in stage III with serum bilirubin of 3.5 mg/dl, albumin of 2.8 g/dl and prothrombia activation of 48%. By eye observation, T-factor was 3, N-factor as 1 and M-factor as 0. She received trans-catheter arterial embolization (TAE) in January, 1994, and 10 mil of lipiodol, 15 mg of ADM and 100 mg of Cisplatin (CDDP) were administered by injection. Then, 200 mg of 5-FU was orally administered for 60 consecutive days but no improvements were observed. In December, 1994, she started taking 55 mg of D-fraction liquid and 6 g of Maitake tablets everyday. As of July, 1995, value of bilirubin was 2.7, albumin 3.1, and prothrombia activation was improved to 63%. She is now diagnosed as stage I. 

 

53 years old, female, Lung cancer (epidermoid carcinoma)
In November, 1993, she was diagnosed as stage III-A according to the TNM classification by UICC (Unia Intern Contra Cancrum). CDDP 80 mg/m, CPA 350 mg/m and ADM 50 mg/m were administered. However, she gave up taking these chemos in March, 1994, because of severe side effects. Since then, she took 100 mg/m of Etoposide with 50 mg of D-fraction and 4 g of tablets. After 14 months, she improved to stage I. 

 

71 years old, male, Lung cancer (epidermoid carcinoma)
He was diagnosed as advanced stage IV but refused to take chemotherapy. He had taken D-fraction 70 mg and 6 g tablets everyday but unfortunately died 20 months later. However, he showed improvement and was diagnosed as stage III-A before he died. As he was told he had only 3 months to live by his doctor, Maitake must have contributed to extending his life for 17 more months. T-factor 2 means that tumor size is more than 3 cm and tumors advanced to the hilus. N-factor 2 means that tumor metastasized to lymph nodes (homolaceral mediaspinum). M-factor1 means that there is remote metastasis. 

 

45 years old, female, Breast cancer (intraductal carcinoma)
ER+ (Estrogen receptor positive) was observed on this patient who had 1.8 cm dia. of tumor focus and had the rigid pleura. In April, 1992, she had surgery to remove the focus and then received mild chemotherapy such as 5-FU and ADM until February, 1994, but a cancer recurrence (diameter of focus 0.9 cm) was found in April, 1994. She refused to undergo surgery at this time, and started taking 100 mg of D-fraction and 5 g of Maitake tablets every day for 6 months. After 6 months, the dose of D-fraction reduced to 50 mg a day. As of may, 1995, it was confirmed that the recurred tumor focus disappeared. 

 

44 years old male, Brain tumor (astrocytoma)
This is an example of an effective trial of D-fraction therapy against a brain tumor. The patient has taken 100 mg of D-fraction and 6 g of Maitake tablets every day for 4 months without taking any other medication including chemotherapy or radiation. In this case, the patient showed dramatic improvement. He had received chemotherapy (CCNU) in four cycles since February, 1994. But he could not accept it because of severe side effects and received no treatment for four months before starting Maitake administration. After 4 months since he started taking Maitake, a complete regression of an egg-sized tumor focus was confirmed.
It can not be concluded that Maitake D-fraction and crude powder alone have the strong anti-cancer activities in human cancer. It should be noted, however, that most of the patients under the Maitake treatment claimed improvement of overall symptoms, even when the tumor regression was not observed. Various side effects from chemotherapy such as lost appetite, vomiting, nausea, hair loss and leukopenia (deficiency of white blood cells) were ameliorated by 90% of the patients. Reduction of the pain was also reported by 83% of the patients. 

 

Preventing Cancer Metastasis
Another interesting of investigation was whether the formation of secondary focus due to metastasis of cancer cells could be inhibited. This test was conducted using mice in the following manner; MM-164 liver carcinoma (1 x 107 cells) was injected to left rear footpad of mice and the footpad was cut off after 48 hours. Then, normal feed was given to the control group (A), 20% Maitake powder was given to group (B) and 1 mg/Kg of D-fraction was given to group (C) with normal food. All three groups were bred for another 30 days, and the number of tumor focus metastasized in the liver was counted by microscope. It was observed that the metastasis to the liver was prevented by 91.3% by the administration of D-fraction and by 81.3% by Maitake powder. It is believed that tumor cells present in blood and/or lymph were necrotized by the activated cellular immune-competent cells. The result of this animal test indicates that cancer metastases could be reduced to less than one tenth by the use of Maitake D-fraction daily. 

 

Synergistic Effect with Chemotherapy
Maitake does not kill cancer cells directly. It stimulates the activities of immune-competent cells and potentiates their action against cancer cells. Chemotherapy is supposed to kill cancer cells directly. Which is more effective in terms of cancer growth inhibition? Here are some interesting results from our study on this effect. We used Mitomycin C (MMC), probably the most popular antibiotic used for various cancer treatments, despite its very severe side effects. In this animal test, Maitake D-fraction, MMC , and D-fraction and MMC together (cutting each dose by half) were injected into tumor-bearing mice respectively. As can be seen in Figure 3, D-fraction alone demonstrated superior tumor growth inhibition to that of MMC (about 80% vs 45%). When MMC and D-fraction were given together, cutting each dose by half, tumor inhibition was further enhanced (nearly 98%). The result indicates some synergistic effect between MMC and Maitake, i.e., tumor cells are directly attacked by MMC while the immune system is activated by D-fraction. Chemotherapy is sometimes very harmful as it significantly lowers the immune system of the patients. We have seen many advanced cancer patients recover from severe side-effects caused by chemotherapy by taking Maitake D-fraction (orally) as an adjuvant. From the above studies, it appears that Maitake and chemotherapy work together, and Maitake has proven to be a valuable adjuvant in the chemotherapeutic treatment of cancer. 

 

Conclusion
Since the cultivation method of Maitake mushroom was established in mid 1980’s, this legendary and delicious mushroom has gained much popularity among Japanese people. Anecdotes and folklore on its medicinal values have also been elucidated by a number of mycologists and pharmacologists and its strong anti-tumor activity has attracted many researchers. It should be noted that, unlike many other mushroom extracts that have to be injected intravenously, Maitake D-fraction has a strong ability to inhibit tumor growth when given orally as well. In this context, various tests were conducted focusing on inhibition of growth and metastasis of cancer after surgery, by oral administration of Maitake. Even though this was a limited and non-controlled trial, the clinical study indicated that Maitake D-fraction is effective against such cancers of the breast, lung, liver, prostate and brain. Both human and animal tests demonstrate a synergistic effect with chemotherapy while ameliorating severe side effects from chemotherapy. Though the data is preliminary, the results of animal (and limited clinical ) studies based on Maitake D-fraction suggest significant healing and preventing potential for cancers and other immune-related health disorders. It is important to note that even among Maitake Mushrooms ( Grifola-frondosa), there are many strains and some contain very little Beta-glucan, the active ingredient to stimulate the immune system. From such strains of Maitake, D-fraction may not be obtained.

Acknowledgements: The author acknowledges Maitake Products, Inc. 222 Bergen Turnpike, Ridgefield Park, NJ 07660 for supplying the Maitake D-fraction and Maitake crude powder.

 

 

References

Medicina ortomolecular

A medicina ortomolecular constitui um ramo da chamada medicina alternativa no qual se acredita que as doenças são resultado de desequilíbrios químicos. Assim, os tratamentos ortomoleculares buscam a restauração dos níveis de vitaminas e minerais considerados ideais no organismo.

Medicina Ortomolecular é o ramo da ciência cujo objetivo primordial é restabelecer o equilíbrio químico do organismo. Este acerto (orto=certo) das moléculas se dá através do uso de substâncias e elementos naturais, sejam vitaminas, minerais, e/ou aminoácidos.

Estes elementos,além de proporcionarem um reequilíbrio bioquímico, combatem os radicais livres. Mas por que o organismo se desequilibra? Para entendermos como isto se dá, podemos partir de uma analogia. O organismo é uma máquina que está permanentemente se produzindo.

 Durante este processo de produção podem surgir falhas, seja na chegada de matéria-prima (vitaminas, minerais, etc.), seja na própria integração de todo e qualquer sistema que compõe a máquina.

Estes sistemas devem trabalhar de forma harmoniosa, como uma engrenagem. Estas engrenagens são os sistemas : NEUROENDÓCRINO, PSÍQUICO E IMUNE. Qualquer falha em algum ponto ou mecanismo desta máquina (ser humano) compromete toda a produção (vida), surgindo os defeitos (doença). Por exemplo: uma pessoa deprimida tem mais chances de apresentar infecções recorrentes, já que uma falha no sistema psíquico leva conseqüentemente a alterações no sistema imune.

Outro fator importante na gênese de várias enfermidades, como artrite e câncer, é a formação de radicais livres. Podemos entendê-los da seguinte forma: o organismo utiliza cerca de 98 a 99% do oxigênio que consumimos para produzir energia. A pequena parcela que sobra (1 a 2%) não participa do processo, formando as espécies tóxicas reativas do oxigênio – os radicais livres. Estes correspondem a átomos ou grupos de átomos com um elétron não emparelhado em sua órbita mais externa, sendo, portanto, muito reativos pois para recuperar o equilíbrio precisam ‘doar’ o elétron desemparelhado.

Desta forma, combinam avidamente com as várias estruturas celulares do corpo, o que resulta em destruição e, conseqüentemente, em enfermidades. Entre estas podem ser citadas o câncer, osteoartrite, lúpus, enfisema e doenças cardio vasculares. O Homem está sendo permanentemente submetido a condições que levam ao excesso de radicais livres como, por exemplo, o estresse, o fumo, a poluição, exposições prolongadas ao sol, entre outras.

A Medicina Ortomolecular, através do uso de vitaminas e minerais, objetiva, entre outros, neutralizar os efeitos tóxicos destas espécies reativas, proporcionando uma melhor qualidade de vida. A Medicina Ortomolecular também trata das deficiências de uma série de nutrientes. Sabe-se, por exemplo, que um fumante gasta 25 mg de vitamina C a cada cigarro que consome.

Caso esta pessoa fume um maço por dia, estará perdendo 500 mg desta vitamina diariamente. E, hoje em dia, sabemos os inúmeros benefícios que esta vitamina proporciona, seja no combate a radicais livres, na síntese de hormônios, ou mesmo estimulando o sistema imunológico. Todavia, apesar da medicina ortomolecular ter um sentido curativo, ela também é eminentemente preventiva. Assim, p. ex.,é possível tratar uma pessoa com estresse antes que ele evolua para uma hipertensão arterial. Da mesma forma, é possível tratar obesidade antes que ela ocasione diabetes. O mais importante é que com a Medicina Ortomolecular o paciente volta a ser encarado como um todo, um conjunto que deve funcionar em harmonia.

Com esta visão global, qualquer tratamento torna-se muito mais vantajoso, pois encontra a origem dos problemas, a verdadeira raiz a partir da qual todo o processo patológico se desenvolve.

Ou ,ainda, voltando à analogia, se encontrarmos o defeito exatamente onde ele origina-se na máquina, é muito mais fácil consertá-la antes que o problema atinja toda a produção, que nada mais é do que a própria vida.

 

Orthomolecular medicine

 

Biologically based alternative
and complementary therapy
edit

NCCAM classifications

1.    Alternative Medical Systems

2.    Mind-Body Intervention

3.    Biologically Based Therapy

4.    Manipulative Methods

5.    Energy Therapy

See also

Orthomolecular medicine is a form of complementary and alternative medicine with the goal of preventing and treating disease with optimal amounts of substances which are natural to the body. These often take the form of nutrients in modified diets with additional dietary supplements, eliminating deleterious substances and food artifactssuch as allergens, refined foods, sugar and transfats.

The term “orthomolecular” was first coined in a 1967 letter by Nobel Prize winner Linus Pauling and later elaborated on in a 1968 paperon

micronutrients and psychiatry to express the idea of “the right molecules in the right amounts” (ortho is Greek for rightin  this paper, Pauling indicated that

the right molecules are “substances that are normally present in the human body.”

Orthomolecular medicine began with a particular focus upon mental illness, and orthomolecular psychiatry remains a major subdiscipline Proponents state that orthomolecular treatments are based on patients’ personal biochemistries and employ naturally-occurring or bioequivalent biomolecules, particularly nutrients such as vitamins, dietary minerals, proteins, antioxidants amino acids, lipotropes prohormones, dietary fiber, fatty acids and other similar substances as well as various digestive factors.

Some megavitamin therapies can be classified as components of orthomolecular medicine. Orthomolecular practitioners often recommend levels beyond the Recommended Daily Allowance, especially for vitamin C, and prescribe the removal of unhealthy foods from the diet. Megavitamin therapies have become relatively popular, with a survey in 2002 finding that approximately one in twenty-five US adults use high doses of vitamins as a form of therapy with this being particularly common in people diagnosed with cancer.

Nutrients are useful in preventing and treating some illnessesbut the mainstream medical consensus is that the broad claims of disease treatment by advocates of orthomolecular medicine are unsubstantiated by the available evidence.The American Medical Association stated in 1997 that “much of the dietary intervention stressed by alternative healers is prudent and reasonable”, but described as a “myth” the idea that “most diseases are caused by faulty diets and can be prevented by nutritional interventions”.

Critics have described some aspects of orthomolecular medicine as food faddism or quackery Research on nutrient supplementation in general suggests that some nutritional supplements might be beneficial, and that others might be harmful.